This Thursday night, the San Francisco 49ers (6-7, 5-8 ATS) host the Los Angeles Rams (7-6, 6-7 ATS) in the NFL’s Week 15 opener from Santa Clara, California. With the top Pennsylvania sportsbooks, you can wager on all the action from this NFC West rematch, which has conference playoff implications.

The 49ers are now tied with a number of other teams and two games behind the final postseason spot, placing them outside the NFC’s playoff picture. In contrast, the Rams defeated the Buffalo Bills 44-42 to record their largest victory of the season.

Best prop bets today for Thursday Night Football

This Thursday Night Football game offers lots of chances for bettors looking to place the finest prop bets.

Kyren Williams anytime TD (-188)

Where: Sportsbook Bet365

Why: Regardless of position, Kyren Williams has been among the league’s most productive players this season. With 12 rushing touchdowns so far this season, the gifted third-year running back has already tied his career-high and is second in the NFL in total touchdowns scored (14) overall. The San Francisco defense, whom he will face, has had trouble holding back opposing running backs this season.

In 10 out of 13 games this season, including the previous three weeks, Williams has exceeded his anytime TD player prop wager. Williams scored three touchdowns in their first meeting back in Week 3 and now faces a 49ers run defense that has given up the second-most rushing touchdowns to running backs so far (14).

Over the past five weeks, San Francisco has let six different rushing backs reach the end zone. The 49ers have given up six rushing touchdowns to the position in their last four games, the most in the league during that time.

In his brief career, Williams has dominated the 49ers, scoring five goals in two games against San Francisco.

You can wager on Kyren Williams at any time TD (-188).

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George Kittle over 57.5 receiving yards (-125)

For example, Caesars Sportsbook

Why: George Kittle is still one of the league’s best tight ends at catching passes. He is coming off a huge performance in Week 14, where he recorded 151 receiving yards and caught all six receptions that were thrown to him. Kittle is one of the best choices in a Niners offense that has been severely hampered by injuries.

In eight of his eleven games this season, including seven of his previous eight, Kittle has lost his receiving yards prop bet. When it comes to defending throws to the tight end position, the Los Angeles defense ranks thirteenth. The Rams have given up tight ends an average of 55.8 receiving yards per game.

Since the team’s Week 9 bye, Kittle has averaged 74.3 receiving yards per game, good for third place among all tight ends this season with 800 yards. Kittle has averaged 66.6 receiving yards per game in 12 outings versus the Rams.

In three of his last four home games versus Los Angeles, Kittle has exceeded this prop bet total.

Place your bet now: George Kittle will gain more than 55.5 receiving yards (-125)

Brock Purdy over 19.5 passing completions (-130)

FanDuel Sportsbook is where

Why: The 49ers don’t have much of a backfield going into this Week 15 game, which puts their postseason aspirations on the line. The starting running back for San Francisco in Week 14 exited the game with an injury of his own, and the team’s top two running backs are on the injured reserve. The Niners will probably rely on Brock Purdy to move the ball if they want to do so against the Rams at this point.

Although Purdy’s season has been mixed, the team has recently had to depend more on him because of those injury concerns. Purdy has completed at least 20 passes in three of his previous four games, despite the fact that he has fallen short in eight of his 12 outings this season.

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The Rams encounter more than 30 pass attempts per game (ninth-most) and rank 19th in terms of the completion percentage allowed (65.7%). In seven of their last eight games, Los Angeles has given up at least 20 completions to the opposition’s quarterback.

Purdy averages precisely 19.5 passing completions per game in his two career games against the Rams, surpassing his total for this prop bet once. Earlier this season, in their Week 3 matchup against Los Angeles, he completed 22 of 30 passes.

Place your bet now: Brock Purdy will pass 19.5 times (-113)

Puka Nacua over 7.5 receptions (+115)

Where: Sportsbook DraftKings

Why: Coming off a dominant performance against the Bills in Week 14, Puka Nacua has been one of Matthew Stafford’s most dependable targets when he’s available for the past two seasons. Nacua received 162 receiving yards and a touchdown in that game after catching 12 of the 14 passes that were thrown to him. Additionally, he found the end zone on the ground after running the ball five times.

Since returning from injury seven games ago, Nacua is tied for sixth place in terms of most targets (71) with 75 in his eight appearances this season. He made 50 catches during that time, averaging 7.1 receptions per game. In three of his last five games, he has witnessed the over hit on his prop bet on receptions.

San Francisco’s defense has given up 50 catches to the position (ninth-highest) on 70 targets over the past four weeks, despite the Niners having one of the more stringent defenses against opposing wide outs.

Although Nacua has only faced the 49ers twice in his career, he has been effective in those games, recording 19 receptions and 188 receiving yards.

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Bet now: Puka Nacua will receive more than 7.5 receptions (+115).

Cooper Kupp anytime TD (+140)

Where: Sportsbook BetMGM

Why: Going into this Thursday Night Football rematch between the Rams and 49ers, Cooper Kupp may be the most well-known figure on the list. The former All-Pro has made six touchdown grabs so far this season, which ties him for 14th most, but he has done it in far less games (9) than the other players at the top of that list. He has lost time due to injuries this season.

Since Kupp has covered this prop in three of his last four games, anytime TD prop gamblers have been pleased with his recent run. Even though the 49ers defense has only given up 11 wide receiver receiving touchdowns all season, San Francisco’s secondary has recently been more vulnerable.

Over the past four games, the Niners have given up four wide receiver receiving touchdowns, which is tied for ninth-most in that time frame. San Francisco is ranked 15th in terms of passing touchdown percentage (4.4) and has given up 17 passing touchdowns overall this season.

Kupp has scored touchdowns in two of his last three games against San Francisco, and he has been quite productive in nine career games against the 49ers.

Place your wager now: Cooper Kupp at any time TD (+140).

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