The San Francisco 49ers will play the Buffalo Bills in the Northeast on Sunday.
The 49ers are keen to improve their season following consecutive defeats to the Seahawks and Packers. The Bills, meanwhile, are only one game behind the AFC’s top spot and are feeling great following a convincing victory against the Chiefs.
Can San Francisco get back on track against one of the best teams in the league now that Christian McCaffrey is healed and Brock Purdy might be making a comeback? For Sunday’s Week 13 action, check out the most competitive betting odds at the top Pennsylvania sportsbooks.
49ers Still In Playoff Hunt
Few teams can begin the season with a 5-6 record and still be in the running for the playoffs, but that is exactly where the San Francisco 49ers are.
The Seahawks are in first place with a 6-5 record, while San Francisco is last in the NFC West just one year after winning the Super Bowl. With six games left in the season, the Niners are just one game away from first place. They must move quickly, but there is still time. Right now.
Since recovering from his Achilles injury, McCaffrey has sadly struggled; in his last three games, he has averaged just 3.5 yards per carry.
Purdy, who has thrown for 13 touchdowns and eight interceptions this season, has also performed below expectations. Additionally, the team’s expectations of making the playoffs and his availability for this weekend remain uncertain.
49ers vs. Bills Odds
On Sunday, the Buffalo Bills are seven points ahead of San Francisco at home. The Niners are 4-7 ATS this season, while Buffalo is 7-4 against the spread.
The point total was originally set at 47 points by the oddsmakers, but it has now fallen to 44.5 points. While San Francisco has a 6-5 over record in 2024, the Bills have outscored the point total in seven of their 11 games.
Buffalo Look To Take Top Seed From KC
Last week’s decisive victory over Kansas City at home moved the Bills within one game of the AFC’s top seed. They now have the tiebreaker against the Chiefs.
Buffalo has scored 30 points or more in five straight games and has won six in a row. With just six games remaining, Josh Allen and the Bills offense are playing at their peak and are headed in the right direction.
It is quite likely that the Bills will surpass the Chiefs as the top seed, given how closely Kansas City has played the majority of its opponents this season. To do that, though, they need to continue winning, which makes every game from now until the end of the regular season even more important.
49ers vs. Bills Betting
Should we worry about McCaffrey now? Not exactly. Three weeks after recovering from an Achilles injury, the NFL’s top rushing back has only managed to average 3.5 yards per carry and has not been able to reach the end zone.
Indeed, Buffalo is now the superior team and gives opponents the fifth-fewest total yards at home among all NFL teams.
However, based on his snap count average (52.0) during his three 2024 games, McCaffrey will have plenty of chances to find the end zone. For running backs in the NFL, that is presently the second-highest average number of snaps per game. On Sundays, I like C-Mac to locate the end zone.
Pick: Caesars Sportsbook’s Christian McCaffrey Anytime TD (-119)
49ers vs. Bills Prediction
With at least 30 points in five consecutive games, Buffalo has been playing some of its finest ball in recent weeks.
At home, the Bills have also been a stalwart defense, limiting opponents to the fifth-fewest total yards and the eleventh-fewest points per contest.
The Niners are also injured, and it’s still unknown if Purdy will play in this game. There is no assurance that he will be 100% even if he plays.
Buffalo is one of the hardest teams to defeat on the field, and I don’t trust San Francisco’s offense at the moment.
On Sunday, that ought to happen once more.
Pick: FanDuel Sportsbook, Buffalo Bills -6.5 (-120)
Note: Every piece of content is rigorously reviewed by our team of experienced writers and editors to ensure its accuracy. Our writers use credible sources and adhere to strict fact-checking protocols to verify all claims and data before publication. If an error is identified, we promptly correct it and strive for transparency in all updates, feel free to reach out to us via email. We appreciate your trust and support!