WHO

Buffalo Bills vs San Francisco 49ers

WHEN

Sunday, December 1st, 8:20 p.m. E.T.

WHERE

Highmark Stadium | Orchard Park, NY

WATCH

NBC, Peacock

In a thrilling game in western New York, the Buffalo Bills (9-2, 7-4 ATS) take on the San Francisco 49ers (5-6, 4-7 ATS) to round up the NFL’s Week 13 Sunday schedule. Some viewed this game as a possible Super Bowl preview going into the season, but the Niners’ injuries and patchy play make that a far less likely scenario now. Prop bets like anytime touchdowns are still a good option for the Bills-49ers because this game still has a lot of elite offensive potential.

At Pennsylvania’s top sportsbooks, picking Anytime Touchdowns is still one of the most popular bets. Even the most experienced bettor may find it challenging to choose the finest anytime TD prop bets due to the large number of participants available. Both teams have game-changing players in this specific match.

Here are the greatest betting odds for the Bills vs. 49ers game before we move on to the top anytime TD prop bets.

Christian McCaffery Anytime TD (-125)

Were: Sportsbook DraftKings

Why: Despite having a mostly forgettable 2024 season, Christian McCaffery has an opportunity to turn things around on Sunday. Against a Bills defense that has struggled in recent weeks against opposing running backs in the passing game, McCaffery should be able to find the endzone in his fourth game of the season. This will be particularly true if Brock Purdy makes a comeback for the Niners.

Place a wager right now:Anytime TD by Christian McCaffery (-125)

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James Cook Anytime TD (-110)

Where: Sportsbook Bet365

Why: James Cook has been among the NFL’s top running backs this season, and his play so far has virtually guaranteed him a spot in the Pro Bowl. With 10 running touchdowns going into Week 13, he is tied for fourth place in the league. The Bills are on the verge of winning another AFC East division title because to his ability to pound the ball over the goal line. He is a good anytime TD prop bet choice this week because he will be up against a porous Niners run defense.

Place a wager right now:Anytime TD James Cook (-110)

George Kittle Anytime TD (+250)

FanDuel Sportsbook is where

Why: George Kittle has benefited greatly from the 49ers offense’s laser-like emphasis on its tight ends in the red zone this season. With eight receiving touchdowns this season, Kittle leads all tight ends, which helps those anytime TD prop bets at Pennsylvania’s best sportsbooks. Among all players this season, regardless of position, that number comes in third. This season, the Bills have given up the sixth-most targets to opposing tight ends.

Place a wager right now:George Kittle TD (+250) Anytime

Josh Allen Anytime TD (+125)

Where: Sportsbook Bet365

Why: With a victory in Week 13 and a defeat to the Miami Dolphins, Josh Allen may lead the Bills to yet another AFC East division title. Allen continues to be one of the league’s most adaptable players, outperforming opposition defenses in a variety of ways. Even though Allen’s interceptions have increased recently, he is still a dangerous running threat, particularly when facing a San Francisco defense that has had trouble stopping mobile quarterbacks.

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Place a wager right now:Josh Allen TD (+125) Anytime

Jauan Jennings Anytime TD (+350)

Where: Sportsbook Bet365

Why: Jennings, the four-year wide receiver, might soon be the odd man out in San Francisco because to the upcoming return of Brandon Aiyuk. However, with the most targets (65) and receiving yards (628) on the team, Jennings has been the Niners’ most dependable receiver this season. With four touchdown catches, he leads all San Francisco wide receivers, and the Bills secondary has been vulnerable to strong play.

Place a wager right now:Jauan Jennings TD (+350) Anytime

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